Search results for "Anti-cancer Agent Mechanism database"

showing 1 items of 1 documents

Combined use of PCA and QSAR/QSPR to predict the drugs mechanism of action. An application to the NCI ACAM Database

2009

During the years the National Cancer Institute (NCI) accumulated an enormous amount of information through the application of a complex protocol of drugs screening involving several tumor cell lines, grouped into panels according to the disease class. The Anti-cancer Agent Mechanism (ACAM) database is a set of 122 compounds with anti-cancer activity and a reasonably well known mechanism of action, for which are available drug screening data that measure their ability to inhibit growth of a panel of 60 human tumor lines, explicitly designed as a training set for neural network and multivariate analysis. The aim of this work is to adapt a methodology (previously developed for the analysis of …

Quantitative structure–activity relationshipMultivariate analysisDatabaseArtificial neural networkMechanism (biology)Computer scienceOrganic Chemistrycomputer.software_genreSettore CHIM/08 - Chimica FarmaceuticaComputer Science ApplicationsSet (abstract data type)Mechanism of actionTest setDrug DiscoveryPrincipal component analysisAnti-cancer Agent Mechanism database PCA QSAR/QSPR Mechanism of actionmedicineData miningmedicine.symptomcomputer
researchProduct